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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Rivista di Medicina Nucleare e Imaging Molecolare
A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
Impact Factor 2,413
The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2009 Febbraio;53(1):17-22
Relationship between PET-FDG and MRI apparent diffusion coefficients in brain tumors
Palumbo B. 1,2, Angotti F. 2, Marano G. D. 2
1 Nuclear Medicine Section Department of Surgical, Radiological and Odontostomatological Sciences University of Perugia, Perugia, Italy
2 Center for Advanced Imaging MRI/PET Department of Radiology West Virginia University Robert C. Byrd Health Sciences Center Morgantown, WV, USA
Aim. The aim of this study was to investigate the relationship between 2-deoxy-2[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET) and diffusion-weighted magnetic resonance imaging (DWI) with apparent diffusion coefficients (ADC) in brain tumors.
Methods. Fifteen patients with 18 metastatic brain lesions underwent gadolinium-enhanced fast spoiled gradient echo (Gd-FSPGR), DWI with ADC maps, and [18F]FDG PET. Spherical three-dimensional tumor and contralateral control regions of interest (ROIs) were drawn on Gd-FSPGR, ADC and PET images, Gd-FSPGR being the target for statistical parametric mapping with realigned ADC and PET to calculate ROI ratios; linear regression analysis was performed.
Results. An inverse correlation (r2=0.2746, P=0.0256) was found between PET and ADC ratios; plotting ratios: when PET ratios were high, ADC ratios were low, while, when ADC ratios were high, PET ratios were low.
Conclusion. Our preliminary data suggest an inverse relationship between PET and ADC indices. Hypercel-lular areas could increase impedance to water diffusion, resulting in low ADC values and high [18F]FDG uptake, while lower cellularity areas show increased ADC with decreased [18F]FDG uptake.