Home > Riviste > The Quarterly Journal of Nuclear Medicine and Molecular Imaging > Fascicoli precedenti > The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2009 February;53(1) > The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2009 February;53(1):3-8

ULTIMO FASCICOLO
 

ARTICLE TOOLS

Estratti

THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Rivista di Medicina Nucleare e Imaging Molecolare


A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the Society of Radiopharmaceutical Sciences and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
Impact Factor 2,481


eTOC

 

ORIGINAL ARTICLES  FREEfree


The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2009 February;53(1):3-8

Copyright © 2009 EDIZIONI MINERVA MEDICA

lingua: Inglese

Feasibility of the sentinel node biopsy in anal cancer

Mistrangelo M. 1, Bellò M. 2, Mobiglia A. 1, Beltramo G. 3, Cassoni P. 4, Milanesi E. 5, Cornaglia S. 1, Pelosi E. 2, Giunta F. 2, Sandrucci S. 3, Mussa A. 1

1 Surgical and Oncological Department University of Turin, Molinette Hospital, Turin, Italy 2 Department of Nuclear Medicine University of Turin, Molinette Hospital, Turin, Italy 3 Department of Radiotherapy University of Turin, Molinette Hospital, Turin, Italy 4 Anatomo-Patological Department University of Turin, Molinette Hospital, Turin, Italy 5 Oncological Centre for Gastrointestinal Neoplasms University of Turin, Turin, Italy


FULL TEXT  


Aim. Anal cancer is a rare neoplasm. According to a European Organization for Research and Treatment of Cancer multivariate analysis, synchronous inguinal lymph node metastasis occurs in 10-25% of patients and constitutes an independent prognostic factor for local failure and overall mortality.
Methods. Inguinal lymph node status was assessed using the sentinel node technique in 35 patients with anal cancer.
Results. Histology revealed 23 squamous carcinomas, 10 basaloid carcinomas, 1 squamous carcinoma with basaloid areas and 1 spinocellular epithelioma associated with areas of Bowen’s disease. Disease stage was T1 in 5 patients, T2 in 18, T3 in 11 and T4 in 1 patient. Lympho-scintigraphy using a GE Millennium gamma camera was performed after peritumoral injection of 37 MBq of 99mTc colloid. Surgical sentinel node biopsy with a portable Scintiprobe MR 100 (Politech®, Carsoli, Italy) had a detection rate of 97.1%. Inguinal metastases were detected in 7 (20%) patients, in 2 of which metastasis was bilateral.
Conclusion. Given the correlation between prognosis and node involvement, sentinel node biopsy can be considered a simple method for adequate pretreatment staging of anal carcinoma. Use of the technique could avert the need for prophylactic inguinal radiotherapy in N0-N1 patients, thus reducing the morbidity associated with inguinal radiotherapy. Consistent follow-up is required to evaluate long-term results.

inizio pagina

Publication History

Per citare questo articolo

Corresponding author e-mail