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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Rivista di Medicina Nucleare e Imaging Molecolare


A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the Society of Radiopharmaceutical Sciences and to the International Research Group of Immunoscintigraphy
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FOREWORD  NON-STANDARD PET NUCLIDES


The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2008 Giugno;52(2):166-73

lingua: Inglese

Bifunctional chelates for metal nuclides

Brechbiel M. W.

Radioimmune and Inorganic Chemistry Section Radiation Oncology Branch National Cancer Institute, Bethesda, MD, USA


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The use of “non-standard” metallic radionuclides continues to be an expanding field of investigation. Radiolabeling small molecules, peptides, proteins, and up to nano-particles are all areas of active investigation for both diagnostic and therapeutic applications. All require a common variableæthe need for appropriate chelation chemistry for adequate sequestration of the metallic radionuclide that is equal to the intended application. A brief overview of the array of the chelation chemistry options available to researchers and the means for their selection is provided.

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