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A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
Impact Factor 2,413
Online ISSN 1827-1936
ADVANCES IN PET - PART II
Piert M., Carey J., Clinthorne N.
Division of Nuclear Medicine Department of Radiology University of Michigan, MI, USA
In recent years, several probes have been developed to allow for the intraoperative detection of tumor tissue using [18F]fluorodeoxyglucose (FDG). Detector designs include high-energy γ and β probes, as well as combination devices with background rejection capabilities. Some laboratory prototypes and commercialized systems have demonstrated reasonable sensitivities for 511 keV photons and/or b particles emitted from 18F for in vivo use. This review focuses on the ability of these devices to detect tumor deposits in the low-contrast environment of the operating room. Important technical and biological factors that influence tumor-to-background contrast are discussed and potential future applications and developments are highlighted. In addition, we evaluate the limited data on absorbed doses resulting from [18F]FDG administration immediately prior to surgery that indicate acceptable levels of radiation exposure to operating room personnel.