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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Rivista di Medicina Nucleare e Imaging Molecolare


A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the Society of Radiopharmaceutical Sciences and to the International Research Group of Immunoscintigraphy
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The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2005 Dicembre;49(4):319-24

lingua: Inglese

The radiopharmaceutical chemistry of 99mTc-tin fluoride colloid-labeled-leukocytes

Tsopelas B.

Nuclear Medicine Department, RAH Radiopharmacy Royal Adelaide Hospital North Terrace, Adelaide, South Australia


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Tc-99m-tin fluoride colloid is a radiotracer used to label patient white cells, for the diagnosis of infection and inflammation. The scintigraphic technique has been employed in routine clinical practice for approximately 20 years in Australia, yet the chemistry of the radiolabeling agent, and the physiological distribution of 99mTc-leukocytes, are not entirely understood. In this review, the physico-chemical characteristics of 99mTc-tin fluoride colloid are discussed, as well as the in vitro and in vivo distribution of 99mTc-tin fluoride-labeled-leukocytes. Furthermore, important animal and human studies are summarized, that emphasize the clinical usefulness of this radiopharmaceutical tracer in nuclear medicine today.

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