Home > Riviste > The Quarterly Journal of Nuclear Medicine and Molecular Imaging > Fascicoli precedenti > The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2004 September;48(3) > The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2004 September;48(3):207-10

ULTIMO FASCICOLO
 

ARTICLE TOOLS

Estratti

THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Rivista di Medicina Nucleare e Imaging Molecolare


A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the Society of Radiopharmaceutical Sciences and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
Impact Factor 2,413


eTOC

 

ORIGINAL ARTICLES  


The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2004 September;48(3):207-10

lingua: Inglese

Should lidocaine be avoided for local anesthesia in radiation synovectomy?

Schweeger I., Pirich C., Ofluoglu S., Sinzinger H.

Department of Nuclear Medicine University of Vienna, Vienna, Austria


FULL TEXT  


Aim. Leakage is of ­major con­cern ­when per­form­ing radi­a­tion syn­ovec­to­my. Although ­post-treat­ment immo­bil­iza­tion was pro­vid­ed, ­extra-artic­u­lar leak­age of radio­ac­tiv­ity has occa­sion­al­ly ­been ­observed in ­patients receiv­ing ­local anes­the­sia in the ­course of radi­a­tion syn­ovec­to­my. This ­study was per­formed to uncov­er any unfa­vour­able ­effect of lid­o­caine on stabil­ity of 166Ho-­FHMA (fer­rum hydrox­ide mac­ro­ag­gre­gate).
Methods. The radio­phar­ma­ceu­ti­cal was inves­ti­gat­ed in ­bovine ser­um albu­min (BSA) solu­tions (5, 10 mg/ml) at pH 6, 7 and 8. Furthermore, the trac­er was incu­bat­ed for 0, 2, 24, 48 and 120 ­hours in syn­ovi­al ­fluid. In ­both ­series the influ­ence of lid­o­caine-HCl 2% (500, 1000 µl) has ­been eval­u­at­ed.
Results. In BSA test­ so­lu­tions, ­amount of lid­o­caine add­ed [df(2), F=7.82, p-lev­el: 0.00] and pH [df(2), F=7.82, p-lev­el: 0.00] sig­nif­i­cant­ly influ­enced in ­vitro stabil­ity of 166Ho ­labeled ­FHMA (n=72). This find­ing was con­firmed in syn­ovi­al ­fluid [df(2), F=3.82, p-lev­el: 0.03] (n=60).
Conclusion. In an experi­men­tal ­design mim­ick­ing nor­mal and inflam­ma­to­ry con­di­tions in the ­joint, addi­tion of a few mil­li­li­ters of lid­o­caine-HCl fol­lowed by a ­shift ­towards low­er pH-val­ues in syn­ovi­al ­fluid may endan­ger stabil­ity of the car­ri­er-trac­er com­plex 166Ho-­FHMA and there­by ­enhance ­extra-artic­u­lar leak­age.

inizio pagina

Publication History

Per citare questo articolo

Corresponding author e-mail