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A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
Impact Factor 2,413
Online ISSN 1827-1936
Department of Neurosurgery University Hospital, Verona, Italy
Aim. The purpose of this study is to prospectively investigate the prognostic role of somatostatin receptor scintigraphy (SRS) using an 111Indium-labelled somatostatin analogue, Octreotide, in skull base meningiomas (SBMs) treated with γ knife (GK) radiosurgery.
Methods. From December 1997 to March 2000, SRS was performed both before and within 1 year of radiosurgery on 12 patients. Semi-quantitative data were calculated as SRS index; the index decrease was arbitrarily considered significant above 10%. A potential correlation between the decrease in post/pre-GK SRS index and radiosurgical outcome was evaluated.
Results. The follow-up period was at least 30 months in the whole series (median, 43 months). In all 12 patients, the pre-GK SRS index was always >1, averaging 3.73±2.9. A decrease in the post-GK average SRS index (2.35±1.5) was observed. The difference between the pre- and post-GK average values was statistically significant (p<0.03). At the 1st high-resolution magnetic resonance imaging (MRI) follow-up within 1 year of GK, there was no tumor shrinkage in any of the 12 patients of our series. A post/pre-GK SRS index decrease >10% was observed in 9 patients and <10% in 3. Delayed MRI follow-up documeted tumor reduction in all 9 cases having an 111In uptake decrease >10%, with stable imaging in the others (p=0.00024).
Conclusion. Our preliminary findings suggest a prognostic correlation between a decrease in concentration of somatostatin receptors on meningioma cells within 1 year of radiosurgery and delayed meningioma shrinkage.