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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Rivista di Medicina Nucleare e Imaging Molecolare


A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the Society of Radiopharmaceutical Sciences and to the International Research Group of Immunoscintigraphy
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  USE OF RADIOLABELLED PEPTIDES FOR SCINTIGRAPHY IN NON-ONCOLOGIC DISEASES


The Quarterly Journal of Nuclear Medicine 2003 Dicembre;47(4):246-55

lingua: Inglese

Radiolabeled chemotactic cytokines: new agents for scintigraphic imaging of infection and inflammation

Van Eerd J. E. M., Boerman O. C., Corstens F. H. M., Oyen W. J. G.

Department of Nuclear Medicine University Medical Center Nijmegen, Nijmegen The Netherlands


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Several radio­phar­ma­ceu­ti­cals are cur­rent­ly ­used for diag­no­sis of inflam­ma­to­ry and infec­tious dis­eas­es in ­patients. Most inflam­ma­to­ry and infec­tious pro­cess­es can be vis­u­al­ized ­with radio­lab­eled autol­o­gous leu­ko­cytes, cur­rent­ly con­sid­ered to be the ­most appro­pri­ate radio­phar­ma­ceu­ti­cal for ­this pur­pose. This ­agent is ­very ­well ­capable to delin­eate ­most inflam­ma­to­ry and infec­tious ­foci in a rel­a­tive­ly ­short ­time ­after injec­tion. The ­time-con­sum­ing and intri­cate label­ing pro­ce­dure and the han­dling of poten­tial­ly con­tam­i­nat­ed ­blood, how­ev­er ­cause ­that ­there is a ­great inter­est in the devel­op­ment of new radio­phar­ma­ceu­ti­cals com­pris­ing the ­same imag­ing qual­ities but with­out ­these dis­ad­van­tag­es. Besides radio­lab­eled leu­ko­cytes sev­er­al oth­er radio­phar­ma­ceu­ti­cals, ­such as 67Ga-cit­rate, radio­lab­eled ­anti-gra­nu­lo­cyte anti­bod­ies and FDG are ­used to ­image infec­tion and inflam­ma­tion. These ­agents accu­mu­late in infec­tious and inflam­ma­to­ry ­lesions in a non-spe­cif­ic man­ner or ­have sub­op­ti­mal diag­nos­tic char­ac­ter­is­tics. Nowadays, ­there is a ­great inter­est in the devel­op­ment of radio­lab­eled chem­o­tac­tic and chem­o­ki­net­ic cyto­kines ­that accu­mu­late and are ­retained in infec­tious and inflam­ma­to­ry ­foci by spe­cif­ic inter­ac­tion ­with infil­trat­ed inflam­ma­to­ry ­cells. In ­this ­review we ­describe the spe­cif­ic char­ac­ter­is­tics of the chem­o­tac­tic and chem­o­ki­net­ic com­pounds ­that are cur­rent­ly stud­ied as poten­tial radio­phar­ma­ceu­ti­cal to vis­u­al­ize infec­tious and inflam­ma­to­ry ­foci. The char­ac­ter­is­tics of a ­series of cyto­kines (IL-1, IL-2), chem­o­kines (IL-8, PF-4, MCP-1, NAP-2), com­ple­ment fac­tors (C5a, C5adR), chem­o­tac­tic pep­tides (fMLF) and oth­er chem­o­tac­tic fac­tors (LTB4) are ­described. The poten­tials of ­these com­pounds to ­serve as an imag­ing ­agent are dis­cussed.

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