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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Rivista di Medicina Nucleare e Imaging Molecolare


A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the Society of Radiopharmaceutical Sciences and to the International Research Group of Immunoscintigraphy
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ORIGINAL ARTICLES  RADIOPHARMACOLOGY


The Quarterly Journal of Nuclear Medicine 2003 Settembre;47(3):201-8

lingua: Inglese

Imaging matrix metalloproteinase expression in tumors

Li W. P., Anderson C. J.

Division of Radiological Sciences Mallinckrodt Institute of Radiology Washington University School of Medicine, St. Louis, MO, USA


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Matrix met­al­lop­ro­tei­nas­es (MMPs) are ­zinc-depen­dent secret­ed or trans­mem­brane ­enzymes con­sti­tut­ing a fam­i­ly of ­over 21 pro­te­o­lyt­ic mem­bers ­that are ­capable of selec­tive­ly digest­ing a ­wide spec­trum of ­both extra­cel­lu­lar ­matrix (ECM) and non­ma­trix pro­teins. MMPs ­play a crit­i­cal ­role in ­tumor ­growth, angio­gen­e­sis, and met­a­stas­ic pro­cess­es. MMP inhib­i­tors (MMPIs) ­have ­been exten­sive­ly inves­ti­gat­ed as ­anti-­tumor ­drugs, ­although the clin­i­cal ­trials ­thus far ­have ­been dis­ap­point­ing. In ­order to bet­ter under­stand the ­role of MMPs in can­cer ­growth and metas­ta­sis, as ­well as ­improve the ther­a­peu­tic effi­ca­cy of MMPIs, ­there is a ­need to devel­op new pro­ce­dures to ­assess and/or mon­i­tor MMP activ­ity in ­vivo. In addi­tion to deter­min­ing wheth­er MMPs are ­present in ­tumors, it ­would be desir­able to ­have an imag­ing ­agent ­that bet­ter ­probes oth­er pro­cess­es asso­ciat­ed ­with MMP over­pro­duc­tion, includ­ing angio­gen­e­sis and the estab­lish­ment of the ­growth of met­a­stat­ic ­lesions in dis­tant ­organ ­sites. In ­this ­paper we ­review the stud­ies relat­ing to the ­recent devel­op­ment of in ­vivo imag­ing of MMP expres­sion. One of the pur­pos­es of ­this ­review is to dis­cuss the cur­rent stat­us of imag­ing MMP expres­sion, ­which ­includes the ­types of trac­ers ­being devel­oped and the ­types of imag­ing modal­ities avail­able. Although imag­ing MMP expres­sion is a rel­a­tive­ly new ­area of ­research, the ­progress ­thus far is high­ly prom­is­ing.

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