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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Rivista di Medicina Nucleare e Imaging Molecolare
A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
Impact Factor 2,413
THERAPY RESPONSE IN NUCLEAR MEDICINE
Guest Editor: Bombardieri E.
The Quarterly Journal of Nuclear Medicine 2003 March;47(1):41-5
Assessment of therapy response by FDG PET in pediatric patients
Franzius C., Schober O.
Department of Nuclear Medicine, Münster University, Münster, Germany
Little is known about the clinical value of FDG PET for assessing treatment response in pediatric oncology. After systematic review of literature, the very few publications concerning response control in pediatric oncology using FDG PET are summarized. There were only 4 studies concerning FDG PET in the assessment of therapy response in pediatric patients. None of the publications fulfilled the requirements for high quality studies because of the small number of patients studied. The clinical value of FDG PET in the assessment of therapy response in pediatric oncology is likely in osseous sarcomas and possibly in high-grade brain tumors. In other pediatric tumor entities such as lymphomas, soft-tissue sarcomas, germ cell tumors, or neuroblastomas, the clinical usefulness of FDG PET can either be assumed analogous to adults, or can be assumed from staging studies, or is still unknown. There is a need for large, systematic studies evaluating FDG PET in therapy monitoring, but also in grading, staging, and in the diagnosis of recurrences in pediatric malignancies.