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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Rivista di Medicina Nucleare e Imaging Molecolare


A Journal on Nuclear Medicine and Molecular Imaging
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  TECHNOLOGIES AND METHODS IN NUCLEAR MEDICINE
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The Quarterly Journal of Nuclear Medicine 2002 March;46(1):35-47

Copyright © 2009 EDIZIONI MINERVA MEDICA

lingua: Inglese

Advances in animal PET scanners

Del Guerra A., Belcari N.

From the Department of Physics, University of Pisa and INFN Section of Pisa, Pisa, Italy


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Now­a­days, a ­growing ­number of ­research ­groups ­shows a ­great ­interest for the appli­ca­tion of PET and ­SPECT tech­niques to the devel­op­ment of new ­drugs. Pre­lim­i­nary ­studies on ­small ani­mals ­require ­high per­for­mance ded­i­cated scan­ners ­with a ­higher spa­tial res­o­lu­tion and sen­si­tivity ­than ­those of clin­ical ­systems. In ­this ­paper the poten­tial appli­ca­tions of ­such inno­va­tive instru­ments are ­shown ­together ­with a ­brief ­review of the ded­i­cated PET and ­SPECT tom­o­graphs devel­oped world­wide. ­Most of the scan­ners ­have ­been ­built as ­research pro­to­types. ­Only two are com­mer­cially avail­able: ­micro-PET®, ­designed and devel­oped at ­UCLA, Los ­Angeles as a ­research pro­to­type, and now pro­duced and dis­trib­uted by Con­corde Micro­systems Inc. (USA) and ­HIDAC PET pro­duced by ­Oxford Posi­tron ­Systems Ltd. (UK). ­Also in ­Italy, a ­high per­for­mance tom­o­graph, ­YAP-(S) PET able to per­form ­both PET and ­SPECT ­studies, has ­been devel­oped at the Uni­ver­sity of Fer­rara. The tech­nical char­ac­ter­is­tics and per­for­mance of ­this ­scanner are ­described. Tom­o­graphs ­with com­bined ­imaging tech­niques, ­such as PET/CT or ­SPECT/CT, are now ­under ­study in var­ious inter­na­tional ­research cen­ters. The advan­tages of ­this new gen­er­a­tion of ­animal scan­ners ­will be ­briefly out­lined.

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