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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Rivista di Medicina Nucleare e Imaging Molecolare


A Journal on Nuclear Medicine and Molecular Imaging
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  ENDOCRINOLOGY - I
Diagnostic procedures


The Quarterly Journal of Nuclear Medicine 1999 Settembre;43(3):281-90

lingua: Inglese

Imaging sym­pa­thet­ic inn­er­va­tion

Matheja P., Schafers M., Weckesser M., Wichter T., Schober O.

From the Departments of Nuclear Medicine and Cardiology Münster University, Germany


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The auto­nom­ic inner­va­tion of the ­heart mod­i­fies ­most car­diac func­tions. Especially the ­heart ­rate and the ­force of con­trac­tion of myo­cy­tes are mod­ulat­ed by the auto­nom­ic ner­vous ­system. A num­ber of spe­cif­ic neu­ro­trans­mit­ters inter­act ­with recep­tors on ­post- and pre­syn­ap­tic bind­ing ­sites reg­u­lat­ing the com­plex elec­tro­me­chan­i­cal ­system of the ­heart. Disturbances at ­this inter­ac­tion ­result in a varie­ty of car­di­o­neu­rop­a­thies. The clin­i­cal man­i­fes­ta­tions can be ­mild and may ­only con­sist of spo­rad­ic arrhyth­mi­as with­out hemo­dy­nam­ic ­effects. In ­some cas­es how­ev­er the auto­nom­ic dys­func­tion may be ­severe, e.g. in the ­acute ­phase of the Guillain-Barré syn­drome and in ­advanced dia­bet­ic neu­rop­a­thy. At ­present, the ­only avail­able tech­niques to visu­al­ise and quan­ti­tate dis­bal­anced inner­va­tion of the myo­car­di­um are scin­ti­graph­ic modal­ities as sin­gle pho­ton emis­sion tomog­ra­phy (­SPECT) and posi­tron emis­sion tomo-g­ra­phy (PET) ­with appro­pri­ate radio­phar­ma­ceu­ti­cals. These meth­ods are ­reviewed ­with ­respect to ­their pos­sible clin­i­cal appli­ca­tion and to ­future devel­op­ments.

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