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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Rivista di Medicina Nucleare e Imaging Molecolare


A Journal on Nuclear Medicine and Molecular Imaging
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The Quarterly Journal of Nuclear Medicine 1999 June;43(2):140-54

lingua: Inglese

PET meas­ure­ments of dopam­i­ner­gic path­ways in the ­brain

Perlmutter J. S. 1,2,4, Moerlein S. M. 3,4

From the 1 Departments of Neurology and Neurological Surgery, 2 Anatomy and Neurobiology, 3 Biochemistry and Molecular Biophysics, 4 Mallinckrodt Institute of Radiology, Washington University School of Medicine St. Louis, Missouri, USA


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Positron emis­sion tomog­ra­phy (PET) meas­ure­ments of dopam­i­ner­gic path­ways ­have ­revealed sev­er­al new ­insights ­into the ­role of dop­a­mine in the pathoph­y­sio­lo­gy and phar­ma­col­o­gy of ­brain dis­eas­es ­such as Parkinson’s dis­ease (PD), dys­to­nia and schizo­phre­nia. PET stud­ies of region­al ­blood ­flow or metab­olism iden­ti­fies ­sites of region­al pathol­o­gy. Drug-­induced chang­es in ­flow or metab­olism indi­cate the func­tion of dop­a­mine-medi­at­ed path­ways. Measurements of radio­lig­and bind­ing in vivo ­with PET ­reveals abnor­mal­ities asso­ciat­ed ­with spe­cif­ic dis­eas­es and the ­actions of var­i­ous ­drugs ­that ­affect the dopam­i­ner­gic ­system. Finally, PET meas­ure­ments of the ­uptake of ana­logues of lev­o­do­pa pro­vide ­clues to the func­tion of dop­a­mine path­ways poten­tial­ly impor­tant for diag­no­sis and treat­ment of dis­ease ­like PD.

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