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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

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A Journal on Nuclear Medicine and Molecular Imaging
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ORIGINAL ARTICLES  NEU­RO­PHAR­MA­COL­O­GY


The Quarterly Journal of Nuclear Medicine 1998 September;42(3):193-8

lingua: Inglese

Imaging neu­ro­chem­istry of cerebrovascular disease with PET and SPECT

Hatazawa J., Shimosegawa E.

From the Depart­ment of ­Radiology and ­Nuclear Med­i­cine Akita ­Research Insti­tute of ­Brain and ­Blood Ves­sels, Akita, ­Japan


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Pathoph­y­sio­logy of cereb­ro­vas­cular dis­ease has ­been ­studied by meas­uring cere­bral ­blood ­flow and ­energy metab­olism ­using ­single ­photon emis­sion com­puted tomog­raphy (­SPECT) and posi­tron emis­sion tomog­raphy (PET). ­These param­e­ters are meas­ures for ­brain ­tissue con­sisting of het­er­o­ge­neous com­po­nents ­such as neu­rons, ­glial ­cells, and ­blood ves­sels. It is ­still dif­fi­cult to eval­uate ­brain dam­ages spe­cif­i­cally ­involving ­either neu­rons or ­other com­po­nents. Sev­eral ­trials ­were ­recently con­ducted to vis­u­alize ­neuron-spe­cific ­injury in cereb­ro­vas­cular dis­ease by ­means of 11C flu­maz­enil for PET and 123I iomaz­enil for ­SPECT. ­These ­tracers selec­tively ­bind to cen­tral ben­zod­i­az­e­pine ­receptor ­which is ­purely neu­ronal. A ­reduced accu­mu­la­tion of ­these ­ligands was ­found in the ­area sur­rounding the com­plete infarc­tion and in the ­cortex ­remote ­from putam­inal hem­or­rhage, indi­cating the exis­tence of ­neuron spe­cific ­injury not vis­u­al­ized by CT and MR. Neu­ro­log­ical def­i­cits ­were ­well cor­re­lated ­with the ­loss of cor­tical accu­mu­la­tion of ­these ­ligands. ­These pre­lim­i­nary ­studies indi­cated a poten­tial of neu­ro­chem­ical ­imaging in cereb­ro­vas­cular dis­ease. Vul­ner­ability to ­ischemia ­which may ­differ ­among ­brain ­tissue com­po­nents, ­among sub­pop­u­la­tions of neu­rons, and ­among pre­-syn­aptic and ­post-syn­aptic func­tions can be ­more pre­cisely exam­ined. Neu­ro­chem­ical ­imaging can be ­also ­applied to ­reveal ­releases and re-or­gan­iza­tion of ­each neu­ro­trans­mitter-­acceptor ­system ­after ­stroke.

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