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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Rivista di Medicina Nucleare e Imaging Molecolare


A Journal on Nuclear Medicine and Molecular Imaging
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The Quarterly Journal of Nuclear Medicine 1998 September;42(3):179-92

Copyright © 2000 EDIZIONI MINERVA MEDICA

lingua: Inglese

Functional imaging of neurotransmitter systems in movement disorders

Ilgin N.

From the Department of Nuclear Medicine Gazi University Medical School, Ankara, Turkey


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PET and ­SPECT ­enable the ­direct meas­ure­ment of com­po­nents of the dopam­i­ner­gic and oth­er ­systems in the liv­ing ­human ­brain and ­offer ­unique oppor­tu­nity for the in ­vivo quan­tifi­ca­tion of the dopam­i­ner­gic func­tion in PD and oth­er move­ment dis­or­ders. The ­need to estab­lish the ear­ly and dif­fe­ren­tial diag­no­sis of PD is increas­ing­ly impor­tant giv­en the ­recent evi­dence ­that ear­ly phar­mac­o­log­ic inter­ven­tion may ­slow pro­gres­sion of ­this pro­gres­sive degen­er­a­tive dis­ease. Accordingly, imag­ing ­with PET and ­SPECT ­using spe­cif­ic neu­ro­mark­ers has ­been increas­ing­ly impor­tant to bio­chem­i­cal­ly iden­ti­fy the ­loss of spe­cif­ic neu­ro­trans­mit­ters, ­their syn­the­siz­ing ­enzymes and ­their recep­tors in move­ment dis­or­ders. Through the par­allel devel­op­ment of new radio­trac­ers, kinet­ic mod­els and bet­ter instru­ments, PET and ­SPECT tech­nol­o­gy is ena­bling inves­ti­ga­tion of increas­ing­ly ­more com­plex ­aspects of the ­human ­brain neu­ro­trans­mit­ter ­systems. This ­paper sum­mariz­es the ­results of dif­fer­ent PET-­SPECT stud­ies ­used to eval­u­ate the var­i­ous ele­ments of the dop­a­mine ­system in the ­human ­brain ­with PET and ­intends to intro­duce the new­ly emerg­ing spe­cif­ic trac­ers and ­their appli­ca­tions to clin­i­cal ­research in move­ment dis­or­ders.

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