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JOURNAL OF NEUROSURGICAL SCIENCES
Rivista di Neurochirurgia
Indexed/Abstracted in: e-psyche, EMBASE, PubMed/MEDLINE, Neuroscience Citation Index, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,651
Journal of Neurosurgical Sciences 2016 Sep 07
Repetitive transcranial magnetic stimulation for pain after spinal cord injury: a systematic review and meta-analysis
Feng GAO 1-4, Hongyu CHU 2, 3, Jianjun LI 1-4, Mingliang YANG 1-4, Liangjie DU 1-4, Jun LI 2, 3, Liang CHEN 2, 3, Degang YANG 2, 3, Hong ZHANG 2, 3, Chetwyn CHAN 5 ✉
1 Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China; 2 Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing, China; 3 School of Rehabilitation, Capital Medical University, Beijing, China; 4 Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China; 5 Applied Cognitive Neuroscience Laboratory, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China
INTRODUCTION: The evidence regarding efficiency of repetitive transcranial magnetic stimulation (rTMS) on relief of neuropathic pain (NP) in patients with prior spinal cord injury (SCI) is controversial. The current meta-analysis aimed to assess the efficacy of rTMS in pain relieve in patients suffering from SCI associated NP.
EVIDENCE ACQUISITION: Medline, PubMed, Cochrane, EMBASE, Google Scholar databases were searched for clinical studies on effects of rTMS treatment on NP caused by prior SCI published before March 14th, 2016 with various combinations of following keywords: transcranial magnetic stimulation, spinal injury, pain. Standardized difference in means with 95% confidence interval was calculated for the change of pain scores after rTMS or sham rTMS treatments.
EVIDENCE SYNTHESIS: A total of two RCTs and 4 cross-over RCTs were included for the meta-analysis. The RCTs recruited a total of 27 patients. The cross-over RCTs recruited a total of 100 patients. The combined standardized difference in means indicated that patients who received rTMS intervention had better pain relief than those who received sham rTMS intervention, however, the results did not reach statistical significance (STD difference in means = -0.607, 95% CI: -1.29 to 0.075, P=0.081).
CONCLUSIONS: rTMS might reduce SCI associated neuropathic pain; however, further studies are required to support our conclusions.