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Indexed/Abstracted in: e-psyche, EMBASE, PubMed/MEDLINE, Neuroscience Citation Index, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,651
Online ISSN 1827-1855
Ceylan D. 1, 4, Tatarlı N. 2, 4, Avsar T. 3, 4, Arslanhan A. 4, Bozkurt S. U. 5, Bağcı P. 5, Seker A. 4, 6, Kilic T. 7
1 Sakarya University, School of Medicine, Department of Neurosurgery, Sakarya, Turkey;
2 Dr. Lutfi Kirdar Kartal Education and Research Hospital, Department of Neurosurgery, Istanbul/Turkey;
3 Istanbul Technical University, Dr. Orhan Ocalgiray Molecular Biology-Biotechnology and Genetics Research Center, Istanbul, Turkey;
4 Marmara University, Neurological Sciences Institute Molecular Neurosurgery Laboratory, Istanbul, Turkey;
5 Marmara University, School of Medicine, Department of Pathology, Istanbul, Turkey;
6 Marmara University, School of Medicine, Department of Neurosurgery, Istanbul, Turkey;
7 Bahcesehir University, School of Medicine, Department of Neurosurgery, Istanbul, Turkey
AIM OF THE STUDY: Increased angiogenic potential of cerebrovascular malformations during pregnancy may help to explain the complications of arteriovenous malformations in this group of patients. This experimental study investigated the effect of pregnancy on angiogenic activity of implanted arteriovenous malformation tissue samples.
METHODS: A subject group of 10 pregnant rats and 10 nonpregnant rats as controls were used. Surgical AVM resection samples were implanted into the micropocket created in both eyes of each animal. Vascular development was assessed by vessel count throughout the study period. In addition, immunohistochemical studies were done for vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF), and their receptors (VEGFR, PDGFR).
RESULTS: Statistically significant increase in the number of vessels was found in both groups (p<0.0001); however, the increase in the pregnant group was greater (p=0.0032). The difference between the two groups was evident at the 25th day of the experiment. Despite both groups showed increased level, there was no difference with the level of VEGF, VEGF receptor, PDGF, or PDGF receptor (p>0.05 for all comparisons).
CONCLUSION: Findings of this study suggest that angiogenic activity of AVM tissues may increase during late pregnancy, hence physicians should inform pregnant patients with AVM of the potential risk.