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Journal of Neurosurgical Sciences 2013 December;57(4):317-26

lingua: Inglese

Application of transport phenomena analysis technique to cerebrospinal fluid

Lam C. H. 1, 2, 3, Hansen E. A. 3, Hall W. A. 4, Hubel A. 2

1 Departments of Neurosurgery University of Minnesota, Minneapolis, MN, USA;
2 Biomedical Engineering, University of Minnesota Minneapolis, MN, USA;
3 Department of Surgery, Minneapolis VA Medical Center, Minneapolis, MN, USA;
4 Department of Neurosurgery State University of New York, Syracuse, NY, USA


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The study of hydrocephalus and the modeling of cerebrospinal fluid flow have proceeded in the past using mathematical analysis that was very capable of prediction phenomenonologically but not well in physiologic parameters. In this paper, the basis of fluid dynamics at the physiologic state is explained using first established equations of transport phenomenon. Then, microscopic and molecular level techniques of modeling are described using porous media theory and chemical kinetic theory and then applied to cerebrospinal fluid (CSF) dynamics. Using techniques of transport analysis allows the field of cerebrospinal fluid dynamics to approach the level of sophistication of urine and blood transport. Concepts such as intracellular and intercellular pathways, compartmentalization, and tortuosity are associated with quantifiable parameters that are relevant to the anatomy and physiology of cerebrospinal fluid transport. The engineering field of transport phenomenon is rich and steeped in architectural, aeronautical, nautical, and more recently biological history. This paper summarizes and reviews the approaches that have been taken in the field of engineering and applies it to CSF flow.

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lamxx023@umn.edu