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Journal of Neurosurgical Sciences 2012 Giugno;56(2):77-85

lingua: Inglese

The actual management of tumor and vertebral compression fractures

Papanastassiou I. D. 1, 2, Aghayev K. 1, Saleh E. 1, Gerochristou M. 3, Vrionis F. D. 1

1 H.Lee Moffitt Cancer Center, Neurosurgical Department, Tampa, FL, USA;
2 General Oncological Hospital “Agioi Anargyroi“, Athens, Greece;
3 “Andreas Syngros” Hospital, Athens, Greece


Tumor related fractures of the spine frequently dictate surgical management. The most critical factors influencing the need and type of surgery are degree of epidural cord compression, radiosensitivity of the tumor, presence of spinal instability and patient medical status/ estimated survivorship. There is a wide spectrum of therapeutic options: major en bloc resections in primary or oligometastatic disease; decompression and fusion in non-radiosensitive tumors with cord compression followed by adjuvant radiation therapy (RT); kyphoplasty/ vertebroplasty for stable compression fractures or minimally invasive corpectomy for more unstable fractures and RT- only for radiosensitive tumors not causing overt instability. Radiation therapy has always been essential component of the treatment algorithm although it has been displaced from principal treatment modality in the last 2 decades. However, the advent of more targeted and efficient forms of RT (radiosurgery) may be a new treatment paradigm for more radioresistant tumors and may obviate the need for major operations.

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