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JOURNAL OF NEUROSURGICAL SCIENCES

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Journal of Neurosurgical Sciences 2007 March;51(1):21-7

Copyright © 2007 EDIZIONI MINERVA MEDICA

lingua: Inglese

Astroblastoma. Case report, review of the literature, and analysis of treatment strategies

Mangano F. T. 2, Bradford A. C. 2, Mittler M. A. 3, Valderrama E. 4, Schneider S. J. 3

1 Department of Pediatric Neurosurgery Cincinnati Children’s Hospital Medical Center Cincinnati, OH, USA 2 Department of Neurosurgery University of Cincinnati College of Medicine Cincinnati, OH, USA 3 Division of Pediatric Neurosurgery Department of Neurosurgery Schneider Children’s Hospital- The Long Island Jewish Medical Center New Hyde Park, New York, NY, USA 4 Department of Pathology Schneider Children’s Hospital- The Long Island Jewish Medical Center New Hyde Park, New York, NY, USA


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Astroblastoma, a unique glial tumor, has been described in the literature in case reports and small series. Its rarity has prevented evidenced-based treatment stratification. An 8-year-old boy presented with signs and symptoms of raised intracranial pressure. Imaging studies of the brain demonstrated a large heterogeneously enhancing solid mass in the left frontal lobe with punctate calcifications and cystic components that created subfalcine and uncal herniation. After tumor resection, histological diagnosis revealed a high-grade cerebral astroblastoma. The child’s postoperative recovery was complicated by hydrocephalus that necessitated placement of a ventriculoperitoneal shunt. Fifty-four months after undergoing gross total resection and adjuvant radiation therapy, the patient, now 12-years-old, remains tumor free and neurologically stable. Chemotherapy was reserved in the event of tumor recurrence. Since the first description of astroblastoma, its histopathological and clinical features have been debated. We review the histology, immunohistochemistry, and cytogenetics of astroblastoma as well as examine the current literature and treatment strategies for the management of both low and high-grade tumors. Continued clinical studies and longer patient follow-up with a tumor based registry would further clarify optimal treatment for this rare tumor

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