Home > Riviste > Journal of Neurosurgical Sciences > Fascicoli precedenti > Journal of Neurosurgical Sciences 2006 Dicembre;50(4) > Journal of Neurosurgical Sciences 2006 Dicembre;50(4):111-7

ULTIMO FASCICOLO
 

ARTICLE TOOLS

Estratti

JOURNAL OF NEUROSURGICAL SCIENCES

Rivista di Neurochirurgia


Indexed/Abstracted in: e-psyche, EMBASE, PubMed/MEDLINE, Neuroscience Citation Index, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,651


eTOC

 

CASE REPORTS  


Journal of Neurosurgical Sciences 2006 Dicembre;50(4):111-7

lingua: Inglese

Aggressive eosinophilic granuloma of the parietal bone. An immunohystochemical study of Ki-67 expression

Bruno M. C. 1, Del Basso De Caro M. L. 2, Panagiotopoulos K. 1, Elefante A. 3, Tortora F. 3, De Notaris M. G. 1, Colella A. 1, Ginguenè C. 4, Cerillo A. 1

1 Department of Neurosurgery School of Medicine, Federico II, Naples, Italy
2 Department of Biomorphological and Functional Sciences School of Medicine, Federico II, Naples, Italy
3 Department of Neuroradiology, School of Medicine Federico II, Naples, Italy
4 Hopital Neurologique Pierre Wertheimer Lyon, France


FULL TEXT  


Solitary eosinophilic granuloma (EG) of the skull is a rare lesion, the natural history of which is still to be defined. We report a case of a 26-year-old female who presented with progressive headache and nausea accompanied by a painful firm mass in her left parietal region, which grew very rapidly during the last two weeks before admission. Computed tomography scan showed an osteolytic lesion, which on magnetic resonance imaging appeared hyperintense on both T1- and T2-weighted images, with marked and heterogeneous enhancement after gadolinium administration. Total surgical excision of the lesion was performed and histopathological diagnosis was compatible with eosinophilic granuloma. Immuno-histochemical study of Ki-67 antigen expression was also performed with a labelling index of 10%. In a review of the pertinent literature, we found one case report showing a Ki-67 labelling index of 6.2% in a patient harboring EG of the occipital bone. These two relatively high percentages of proliferative activity suggest a role of local Langerhans’cell proliferation, along with that of inflammatory response, in the aggressive clinical course and rapid expansion observed in some rare cases of solitary eosinophilic granuloma.

inizio pagina

Publication History

Per citare questo articolo

Corresponding author e-mail