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Journal of Neurosurgical Sciences 2004 Settembre;48(3):117-24

lingua: Inglese

Lymphoplasmacyte rich meningioma. A case report and review of the literature

Bruno M. C. 1, Ginguené C. 2, Santangelo M. 1, Panagiotopoulos K. 1, Piscopo G. A. 1, Tortora F. 3, Elefante A. 3, De Caro M. L. 4, Cerillo A. 1

1 Department of Neurosurgery Federico II University School of Medicine, Naples, Italy
2 Pierre Wertheimer Neurologic Hospital, Lyon, France
3 Department of Neuroradiology Federico II University School of Medicine, Naples, Italy
4 Department of Biomorphological and func­tion­al Sciences Federico II University School of Medicine, Naples, Italy


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A pecu­liar ­type of menin­gio­ma ­with con­spi­cious plas­ma-­cell com­po­nents is ­described. In accor­dance ­with the World Health Organization’s Histological Typing of Tumours of the Central Nervous System, ­this ­rare clin­i­cal ­entity is recent­ly ­designed as lym­pho­plas­ma­cyte ­rich (LPR) menin­gio­ma. This ­type of menin­gio­ma is usu­al­ly accom­pa­nied by prom­i­nent periph­er­al ­blood abnor­mal­ities, ane­mia and/or polic­lo­nal gam­mo­phaty, ­that dis­ap­pear ­after sur­gi­cal remov­al of the ­tumor. Actually, the ori­gin (neo­plas­tic or inflam­ma­to­ry) of ­this ­tumor is ­unclear; its bio­log­i­cal behav­ior and clin­i­cal ­course are anom­a­lous so it is con­sid­ered clos­er to intra­cra­ni­al inflam­ma­to­ry mass­es rath­er ­than typ­i­cal menin­gio­ma. In ­this ­paper, a new ­case of intra­cra­ni­al LPR menin­gio­ma occur­ring in a wom­an, is report­ed and a ­review the lit­er­a­ture is ­made.

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