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Journal of Neurosurgical Sciences 2003 December;47(4):211-4

lingua: Inglese

Meningeal melanocytoma of the temporal lobe. An uncommon tumor in an unusual location. Case report

Aimar E. 1, Debernardi A. 1, Tancioni F. 1, Di Ieva A. 1, Bossi P. 2, Gaetani P 1., Rodriguez Y Baena R. 1

1 Department of Neu­ro­sur­gery Humanitas Clinical Institute, Rozzano (MI), Italy
2 Pathology Section, Humanitas Clinical Institute, Rozzano (MI), Italy


Meningeal melan­o­cy­to­mas are ­rare pig­ment­ed ­tumors of the cen­tral ner­vous ­system. These ­tumors are ­benign mel­a­not­ic ­lesions ­that ­derive ­from the mel­a­noc­y­tes of the lep­to­me­ning­es. They may ­occur any­where in the cra­ni­al and spi­nal menin­ges; how­ev­er, ­they are ­found prev­al­ent­ly in the pos­te­ri­or fos­sa and in the spi­nal ­cord. Their epi­dem­i­olog­i­cal fea­tures, nat­u­ral his­to­ry and ­response to treat­ment ­remain poor­ly under­stood, ­even if, in the ­last 2 ­years, ­some ­reviews ­have ­been pub­lished ­about it. We ­report a new ­case of intra­cra­ni­al supra­ten­to­ri­al menin­geal melan­o­cy­to­ma, in the tem­po­ral ­lobe, occur­ring in a 27-­year-old man, admit­ted to our Institute ­with a ­long-­time his­to­ry of sei­zures. We ­report his­to­log­i­cal and radio­log­i­cal char­ac­ter­is­tics of our ­case, and brief­ly ­review the ther­a­peu­ti­cal ­options report­ed in lit­er­a­ture. Preoperative neu­ro­ra­dio­log­i­cal find­ing is ­unclear; the pre­op­er­a­tive diag­no­sis is usu­al­ly menin­gio­ma, ­because of the ­long dura­tion of symp­tom­a­tol­o­gy and the radio­log­i­cal appear­ance of the ­lesion as an ­extra-­axial ­mass. Diagnosis of ­these ­lesions, as in our ­case, is ­made intra­op­er­a­tive­ly by the ­gross, jet-­black appear­ance of the ­tumor and by his­to­log­i­cal exam­ina­tion. In ­spite of the ­benign bio­log­ic beha­vi­our, the prog­no­sis ­remains uncer­tain, ­because of the pos­sible ­local recur­renc­es. According to the ­results of ­some ­works of the ­last ­years, it ­seems appro­pri­ate to use post­op­er­a­tive radio­ther­a­py for ­those ­patients ­with symp­to­mat­ic resid­u­al, pro­gres­sive or recur­rent ­tumors not amen­able to fur­ther resec­tion.

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