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JOURNAL OF NEUROSURGICAL SCIENCES
Rivista di Neurochirurgia
Indexed/Abstracted in: e-psyche, EMBASE, PubMed/MEDLINE, Neuroscience Citation Index, Science Citation Index Expanded (SciSearch), Scopus
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Journal of Neurosurgical Sciences 2001 December;45(4):195-201
Proposal of a clinico-histological “glioma score” as a prognostic index in high-grade glioma patients. Preliminary observations in a series of 80 cases
Mastronardi L. 1, Guiducci A. 2, Puzzilli F. 1
1 Division of Neurosurgery, Sandro Pertini Hospital, Rome;
2 Institute of Pathological Anatomy, Civilian Hospital, Terni, Italy
Background. Despite of several multimodal treatments, malignant gliomas still have a poor outcome. In order to identify subgroups of patients with different prognosis, we propose a clinical and histological score (GS).
Methods. Eighty consecutive patients operated on for a high-grade glioma and treated with adjuvant therapy entered the study. In relation to age at diagnosis, preoperative Karnofsky Performance Status (KPS), and MIB-1 index, patients have been splitted in 4 groups (GS 0-III).
Results. The overall mean survival of the entire cohort was 18.2 months (median 12). Patients with GS 0 have a mean survival rate of 30.0 months, with GS I 23.1 months, with GS II 12.1 months, and with GS III 9.0 months (p=0.0001). Moreover, mean survival with a KPS ≥70 was 29.0 in GS 0, 26.0 in GS I, 10.0 in GS II, and 0 in GS III patients (p<0.0001).
Conclusions. On the basis of these preliminary observations, we discuss the utility of our “glioma score” as a prognostic indicator for patients operated on for cerebral malignant gliomas and treated postoperatively with adjuvant therapy.