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Journal of Neurosurgical Sciences 2000 December;44(4):230-3

Copyright © 2000 EDIZIONI MINERVA MEDICA

lingua: Inglese

Medulloblastoma in late adults. Case report and critical review of the literature

Salvati M., Cervoni L.

Department of Neurosurgery, Mediterranean Neurological “Neuromed” Institute, IRCCS, Pozzilli, Isernia, Italy


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Background. Medulloblastoma in ­late ­adults (old­er ­than 65 ­years) is an excep­tion­al occur­rence; in ­fact ­only 8 cas­es are report­ed ­with com­plete clin­i­cal ­notes in the lit­er­a­ture.
Methods. The ­authors ­describe a ­case of medul­lo­blas­to­ma occur­ring in a 68-­year-old man and ana­lyzed cas­es report­ed in the lit­er­a­ture.
Results. The over­all aver­age age of the ­patients was 72.8 ­years (­range 67-88 ­years), and the ­male prev­a­lence of ­this ­tumour (70% of cas­es) ­seems to be unre­lat­ed to age. There is a lat­er­al pre­dom­i­nance in ­late ­adults (77.7% of cas­es). Seven ­patients under­went oper­a­tion and sub­se­quent­ly ­these ­patients under­went a ­course of radi­a­tion ther­a­py. Only two ­patient was treat­ed ­with post­op­er­a­tive chem­o­ther­a­py. Median sur­vi­val for sev­en ­patients treat­ed was 43.2 ­months (­range 23-96 ­months).
Conclusions. It is inter­est­ing to ­note ­that: 1) his­to­log­i­cal anal­y­sis ­revealed a clas­sic ­type medul­lo­blas­to­ma (88.8% of cas­es) sim­i­lar to the chil­dren: 2) ­site of the ­tumor is lat­er­al sim­i­lar to the ­adults (77.7% of cas­es).

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