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Journal of Neurosurgical Sciences 2000 September;44(3):123-7

lingua: Inglese

Non-hind­brain-relat­ed syrin­gom­ye­lia. Obstruction of the sub­arach­noid ­space and the cen­tral ­canal in ­rats. An experimental study

Cosan T. E. 1, Tel E. 1, Durmaz R. 1, Gulec S. 2, Baycu C. 3

1 Department of Neurosurgery, Osmangazi University, Eskisehir, Turkey;
2 Department of Anesthesiology, Osmangazi University, Eskisehir, Turkey;
3 Department of Histology and Embryology, Osmangazi University, Eskisehir, Turkey


Background. The aim is to deter­mine the mech­a­nism of non-hind­brain-relat­ed syrin­gom­ye­lia in experi­men­tal mod­els. The ­effects of obstruc­tion of cen­tral ­canal and sub­arach­noid ­space on occur­rence of cav­ities ­were dis­cussed.
Methods. 31 Sprague-Dawley ­rats ­were ­used ­with ­eight (Group D) as a con­trol. In 10 ­rats (Group A) 1.5 µl kao­lin was micro­in­ject­ed ­into the dor­sal col­umns and cen­tral ­gray mat­ter of the spi­nal ­cord at the lev­el of Th6-10. In 10 ­rats (Group B) 0.1 cc kao­lin was inject­ed ­into the sub­arach­noid ­space at the ­same lev­el. In 3 ­rats (Group C), 1.5 µl kao­lin was admin­is­tered ­into ­both dor­sal mid­line of the spi­nal ­cord and the sub­arach­noid ­space.
Results. In Group A, his­to­log­i­cal exam­ina­tion ­revealed cys­tic cav­ity and dil­a­ta­tion of the cen­tral ­canal in ­five ­rats; denud­ed epen­dy­mal ­line and mul­ti­cys­tic for­ma­tions in epen­dy­mal and per­i­epen­dy­mal are­as in sev­en ­rats. In Group B, denud­ed epen­dy­mal ­line in ­three ­rats and micro­cys­tic for­ma­tions in epen­dy­mal and per­i­ependymal are­as in ­four ­rats ­were ­revealed. In Group C, ­there ­were micro­cys­tic for­ma­tions in two ­rats and ­syrinx cav­ity in one rat.
Conclusions. Developments lead­ing to occur­rence of cav­ities are ­focused on the cen­tral ­canal in all ­groups. These mod­els indi­cate ­that the CSF-­flow is ­from the sub­arach­noid ­space to the cen­tral ­canal lead­ing to chang­es of cav­ities. In cas­es of obstruc­tion of the sub­arach­noid ­space or the cen­tral ­canal, the occur­rence of ­syrinx cav­ity initial­ly is due to ­increased CSF (cere­bro­spi­nal ­fluid) pres­sure in the cen­tral ­canal. Flow chang­es in spi­nal ­cord is indi­cat­ed by ­this ­study.

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