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Minerva Urologica e Nefrologica 2016 Oct 21

lingua: Inglese

Current position of diagnostics and surgical treatment for upper tract urothelial carcinoma

Mieke T. BUS 1, Daniel M. DE BRUIN 1, 2, Guido M. KAMPHUIS 1, Patricia J. ZONDERVAN 1, Maria P. LAGUNA PES 1, Theo M. DE REIJKE 1, Ton G. VAN LEEUWEN2, Jean J. DE LA ROSETTE 1

1 Department of Urology, Academic Medical Center, Amsterdam, The Netherlands; 2 Department of Biomedical Engineering & Physics Academic, Medical Center, Amsterdam, The Netherlands


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BACKGROUND: The applicability of urinary biomarkers and optical diagnostics in upper urinary tract carcinoma (UUTUC)
are increasingly debated. To receive insight in the opinion of the urological community involved in this field, a survey was sent out to identify the most promising techniques and understand the need for new diagnostics. Primary objective of this study was to provide an overview of current diagnostics in upper urinary tract urothelial carcinoma. Secondary objectives of this study was to assess the need for additional diagnostic techniques in the current diagnostic work-up for UUT-UC and to assess knowledge of novel techniques.
METHODS: An electronic survey was distributed to all participants of the upper urinary tract tumor registration study by the Clinical Research Office of the Endourological Society. Additionally, based on publications, experts in the field were contacted. Analysis was performed on the results overviewed by the survey monkey website.
RESULTS: In total 81 of the 112 invited individuals responded resulting in a response rate of 72.3%. Most urologists involved in the treatment of upper urinary tract tumours follow the guidelines in their diagnostic work-up of patients suspected for UUT-UC. 61.4% of all responders consider current available diagnostic methods insufficient to select patient candidates for conservative renal sparing surgery. According to the responders, digital endoscopes for retrograde intrarenal surgery (RIRS) including narrow band imaging (NBI) are best known and most likely to be beneficial compared to all evaluated diagnostic tools currently available.
CONCLUSIONS: Urologists consider current diagnostic techniques for upper urinary tract tumours insufficient for optimal patient selection for conservative renal sparing surgery. Among the new techniques, NBI and digital RIRS are best known and considered to be beneficial in the diagnostic work-up.

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m.t.bus@amc.uva.nl