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Minerva Urologica e Nefrologica 2017 April;69(2):195-200

DOI: 10.23736/S0393-2249.16.02500-5

Copyright © 2015 EDIZIONI MINERVA MEDICA

lingua: Inglese

Plasma C1q/TNF-related protein 9: a promising biomarker for diabetic renal vascular injury

Takayuki FUJITA 1, Hidetsuna WATANABE 2, Yusuke MURATA 1, Seiichiro HEMMI 1, Minako YABUKI 1, Yoshinobu FUKE 1, Atsushi SATOMURA 3, Masayoshi SOMA 4

1 Department of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine, Tokyo, Japan; 2 Department of Internal Medicine, Sakuboukai Tokiwadaigeka Hospital, Tokyo, Japan; 3 Department of Laboratory Medicine, Nihon University School of Medicine, Tokyo, Japan; 4 Department of General Medicine, Nihon University School of Medicine, Tokyo, Japan


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BACKGROUND: Adipocytokines are associated with the pathophysiology of type 2 diabetes (T2DM).
METHODS: We analyzed the relationship between levels of the plasma C1q/tumor necrosis factor-related protein 9 (CTRP9) and other adipocytokines or the endothelial function in patients with T2DM, and analyzed their trending manner.
RESULTS: CTRP9 was detected in plasma from 14 out of a total of 28 patients. The values were not normally distributed. In comparing between groups in which CTRP9 was or was not detected, there were statistically significant differences in the high molecular weight adiponectin (HAN) and the urinary albumin/creatinine ratio (ACR). This indicates that both CTRP9 and HAN reflect the pathophysiology of renal involvement in T2DM. HAN correlated with Body Mass Index, ACR, and homeostasis model assessment of insulin resistance. However, CTRP9 did not correlate with HAN or any other parameters.
CONCLUSIONS: CTRP9 independently trends in a different manner from HAN, and may reflect diabetic renal vascular risk in association with atherosclerosis and abnormal glucose metabolism besides of impaired vaso-relaxation in patients with T2DM.


KEY WORDS: Type 2 diabetes mellitus - Insulin resistance - Cytokines - Vascular endothelium - Albuminuria

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Publication History

Issue published online: February 28, 2017
Article first published online: December 3, 2015
Manuscript accepted: November 25, 2015
Manuscript revised: October 28, 2015
Manuscript received: August 3, 2015

Per citare questo articolo

Fujita T, Watanabe H, Murata Y, Hemmi S, Yabuki M, Fuke Y, et al. Plasma C1q/TNF-related protein 9: a promising biomarker for diabetic renal vascular injury. Minerva Urol Nefrol 2017;69:195-200. DOI: 10.23736/S0393-2249.16.02500-5

Corresponding author e-mail

tfujita@med.nihon-u.ac.jp