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Minerva Urologica e Nefrologica 2016 Febbraio;68(1):14-9

lingua: Inglese

Focus on desmopressin and enuresis: a review of literature

Pietro FERRARA 1, Flaminia VENA 2, Maria C. BASILE 2, Francesca IANNIELLO 1, Antonio GATTO 1

1 Institute of Pediatrics, Sacro Cuore Catholic University, Rome, Italy; 2 Campus Bio-Medico University, Rome, Italy


Nocturnal enuresis (NE) is a common disorder in children. Choice of treatment depends on the frequency and severity of symptoms, the child’s age and motivation. Treatment options for NE are alarm, desmopressin and imipramine. In particular, the main desmopressin therapeutical effect is the antidiuretic activity. The different formulations of desmopressin are an injectable solution, an oral tablet formulation and the recent oral lyophilisate (MELT). MELT with its higher biodisponibility guarantees the same therapy response of other formulations with a lower doses and it represents the first line and safety treatment for the NE.

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