Ricerca avanzata

Home > Riviste > Minerva Urologica e Nefrologica > Fascicoli precedenti > Minerva Urologica e Nefrologica 2014 Dicembre;66(4) > Minerva Urologica e Nefrologica 2014 Dicembre;66(4):241-7

FASCICOLI E ARTICOLI   I PIÙ LETTI   eTOC

ULTIMO FASCICOLOMINERVA UROLOGICA E NEFROLOGICA

Rivista di Nefrologia e Urologia

Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,536

Periodicità: Bimestrale

ISSN 0393-2249

Online ISSN 1827-1758

 

Minerva Urologica e Nefrologica 2014 Dicembre;66(4):241-7

 ARTICOLI ORIGINALI

Effects of bethanechol chloride and distigmine bromide on postvoiding residual volume in patients with underactive bladder

Izumi K. 1, Maolake A. 1, Maeda Y. 1, Shigehara K. 2, Namiki M. 1

1 Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan;
2 Department of Urology, Ishikawa Prefectural Hospital, Kanazawa, Japan

AIM: The efficacy of cholinergic drugs for reduction of post-voiding residual volume (PVR) in patients with underactive bladder is still controversial. This study was performed to examine whether cholinergic drugs have such an effect on PVR.
METHODS: Patients with underactive bladder treated for more than two months with cholinergic drugs, which were later discontinued, were extracted retrospectively based on their charts. The changes in PVR, cholinesterase activity (ChE), renal function, and voiding function before and after discontinuation of cholinergic drugs were reviewed and analyzed.
RESULTS: Twenty-nine patients were included in this study. In multiple linear regression analysis, the discontinuation of distigmine bromide (DB) was indicated as a significant covariate for PVR increase and ChE increase, while bethanechol chloride (BC) was not a significant covariate. The increase in ChE was significantly correlated with both PVR and voided volume after discontinuation of cholinergic drugs.
CONCLUSION: DB could reduce PVR via a decrease in ChE. However, BC at doses up to 60 mg did not reduce PVR. DB may be recommended for the reduction of PVR in patients with underactive bladder.

lingua: Inglese


FULL TEXT  ESTRATTI

inizio pagina