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Cinzia MASPERO, Lucia GIANNINI, Vera CARLETTI, Guido GALBIATI, Chiara PREVEDELLO, Giampietro FARRONATO
UOC chirurgia maxillo facciale e odontostomatologia. Fondazione IRCCS, Cà Granda, Ospedale Maggiore Policlinico, University of Milan, Italy
BACKGROUND: The possible relationship between periodontitis and Juvenile Idiopathic Arthritis is now mostly unknown but there are common characteristics in both diseases. The purpose of this study is to evaluate Etanercept (Enbrel®) effects on periodontal conditions of children affected by Juvenile Idiopathic Arthritis.
METHODS: For this study three group of patients were selected. The first one is represented by Juvenile Idiopathic Arthritis subjects in pharmacologic therapy with Etanercept(Enbrel ®). The second one was composed by subjects in pharmacologic therapy with other drugs and the third one by healthy subjects. Twenty subjects for each group were selected. For each subject two periodontal scores were taken: plaque index and bleeding on probing. In order to check the reliability of the method a second registration has been performed in all the 3 groups after one month. A statistic Kruskal-Wallis test has been performed.
RESULTS: Plaque index average is 48% in first group, 37% in second group and 20% in control group. Bleeding index average is 5% in first group, 5% in second group and 9% in control group.
CONCLUSIONS: Most probably Etanercept reduces periodontal inflammation in children affected by Juvenile Idiopathic Arthritis as the other therapy.