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Rivista di Pediatria, Neonatologia, Medicina dell’Adolescenza
e Neuropsichiatria Infantile

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Minerva Pediatrica 2016 Jul 13


lingua: Inglese

Association between the lactate/albumin ratio and mortality in pediatric septic shock patients with underlying chronic disease: retrospective pilot study

Seung J. CHOI, Eun J. HA, Won K. JHANG, Seong J. PARK

Division of Pediatric Critical Care Medicine, Department of Pediatrics, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, Pediatric Intensive Care Unit, Asan Medical Center Children’s Hospital, Republic of Korea


BACKGROUND: We aimed to evaluate the ability of the lactate/albumin ratio to predict mortality in pediatric septic shock patients.
METHODS: Retrospective analysis of the medical records of a pediatric intensive care unit. The study cohort comprised 90 pediatric septic shock patients admitted from February 2012 to May 2015.
RESULTS: The serum lactate and albumin levels and lactate/albumin ratio were compared between survivors and non-survivors. We assessed whether the lactate/albumin ratio could be used to predict mortality. The 28-day hospital mortality was 26.7%(24/90). The lactate level was higher(2.5 ± 2.2 vs 8.1 ± 5.1 mmol/L, p<0.001) and the albumin level was lower(2.9 ± 0.5 vs 2.7 ± 0.5 mg/dL, p=0.063) in non-survivors than in survivors. The lactate/albumin ratio was 0.9 ± 0.8 in survivors and 3.2 ± 2.4 in non-survivors(p<0.001). According to the area under the receiver operating characteristic curve (AUC), the lactate/albumin ratio showed good discriminatory power for predicting mortality (AUC = 0.867). A lactate/albumin ratio exceeding 1.016 led to an 7.636-fold increase in mortality.
CONCLUSIONS: The lactate/albumin ratio is a useful predictor of mortality in pediatric septic shock patients.

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