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Rivista di Pediatria, Neonatologia, Medicina dell’Adolescenza
e Neuropsichiatria Infantile
Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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Minerva Pediatrica 2016 Mar 18
The effect of butylphthalide on amino acid in the brain of epileptic mice
Lin HAN 1, Qingyang WANG 1, Xiaoming LIU 2 ✉
1 Department of Pharmacy, Xuzhou Children's Hospital, Xuzhou, Jiangsu, P.R.China; 2 Department of Neurology, Xuzhou Children's Hospital, Xuzhou, Jiangsu, P.R.China
BACKGROUND: To observe the effect of butylphthalide (NBP) on the amino acid content in the brain of epileptic mice.
METHODS: Butylphthalide (NBP) was injected intraperitoneally into the mice, and acute epileptic mice models were made after 30 min. The change of the four amino (aspartic acid, gamma-aminobutyric acid, glutamate, glycine) content in the brain of the epileptic mice was investigated.
RESULTS: The contents of Glu and Glu/GABA (model group: 38.78, NBP high dose group:5.52) in the NBP high dose group were lower compared with the model group. The difference was statistically significant.
CONCLUSIONS: Butylphthalide could regulate the balance of excitement and inhibition systems by reducing the contents of Glu and Glu/GABA, which might relieve seizures.