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Rivista di Pediatria, Neonatologia, Medicina dell’Adolescenza
e Neuropsichiatria Infantile
Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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Minerva Pediatrica 2016 Mar 17
The value of pancreatic stone protein predicting infected neonates
Rong WU 1, Li ZHA 1, Jin H. HU 1, Jian M. WU 1, Zhao F. TIAN 2 ✉
1 Neonatal Medical Center, Huaian Maternity and Child Health Care Hospital, Yangzhou University Medical School, Huaian, China; 2 Department of Neonatology, Huaian First People's Hospital, Nanjing Medical University, Huaian, China
BACKGROUND: To determine serum Pancreatic Stone Protein (PSP) levels in the neonates with highly probable or probable sepsis and assess their possible value in predicting infected neonates.
METHODS: This was a prospective study involving 119 neonates who were admitted with suspected sepsis. The study population was divided into two groups, a infected group (n=40, with highly probable sepsis or probable sepsis) and control group (n=79, with possible or no sepsis). The blood samples were obtained from 24h, 72h and 168h after birth. The amount of serum PSP were detected by enzyme linked immunosorbent (ELISA).
RESULTS: PSP serum concentrations were higher in the infected group comparison to the control group at all timepoints (all P=0.000). In addition the sequential comparison between the infected group and control group at all of time points was significantly different (F=48.558, P=0.000). ROC area under the curve (AUC) was 0.791 [95 % confidence interval (CI) 0.71-0.87; p=0.000] for PSP at 24h after birth and 0.790 (95 % CI 0.79-0.88; p=0.000) at 72h after birth and combination of the two timepoints (24h / 72h), the AUC was 0.819 (95 %CI 0.74-0.90; p=0.000).
CONCLUSIONS: PSP is a valuable biomarker in predicting infected neonates. Combination of PSP at each timepoint within 72 hours after birth might be better.