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MINERVA PEDIATRICA

Rivista di Pediatria, Neonatologia, Medicina dell’Adolescenza
e Neuropsichiatria Infantile


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Minerva Pediatrica 2016 Mar 17

lingua: Inglese

The value of pancreatic stone protein predicting infected neonates

Rong WU 1, Li ZHA 1, Jin H. HU 1, Jian M. WU 1, Zhao F. TIAN 2

1 Neonatal Medical Center, Huaian Maternity and Child Health Care Hospital, Yangzhou University Medical School, Huaian, China; 2 Department of Neonatology, Huaian First People's Hospital, Nanjing Medical University, Huaian, China


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BACKGROUND: To determine serum Pancreatic Stone Protein (PSP) levels in the neonates with highly probable or probable sepsis and assess their possible value in predicting infected neonates.
METHODS: This was a prospective study involving 119 neonates who were admitted with suspected sepsis. The study population was divided into two groups, a infected group (n=40, with highly probable sepsis or probable sepsis) and control group (n=79, with possible or no sepsis). The blood samples were obtained from 24h, 72h and 168h after birth. The amount of serum PSP were detected by enzyme linked immunosorbent (ELISA).
RESULTS: PSP serum concentrations were higher in the infected group comparison to the control group at all timepoints (all P=0.000). In addition the sequential comparison between the infected group and control group at all of time points was significantly different (F=48.558, P=0.000). ROC area under the curve (AUC) was 0.791 [95 % confidence interval (CI) 0.71-0.87; p=0.000] for PSP at 24h after birth and 0.790 (95 % CI 0.79-0.88; p=0.000) at 72h after birth and combination of the two timepoints (24h / 72h), the AUC was 0.819 (95 %CI 0.74-0.90; p=0.000).
CONCLUSIONS: PSP is a valuable biomarker in predicting infected neonates. Combination of PSP at each timepoint within 72 hours after birth might be better.

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