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Rivista di Pediatria, Neonatologia, Medicina dell’Adolescenza
e Neuropsichiatria Infantile
Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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Minerva Pediatrica 2015 Dec 17
EBV induces HERV-K and HERV-W expression in pediatrics liver transplant recipients?
Bergallo M. 1, 2, Pinon M. 3, Galliano I. 1, 2, Montanari P. 1, 2, Daprà V. 2, Gambarino S. 2, Calvo P. L. 3 ✉
1 Department of Public Health and Pediatric Sciences, University of Turin, Medical School, Turin, Italy;
2 Laboratory of Citoimmunodiagnostics, University Hospital City of Science and Health of Turin, Regina Margherita Children's Hospital, Turin, Italy;
3 Unit of Pediatric Gastroenterology and Hepatology, University of Turin, Città della Salute e della Scienza Hospital, Turin, Italy
OBJECTIVES: Human endogenous retrovirus (HERVs) constitute approximately 8% of the human genome. Induction of HERV transcription is possible under certain circumstances, and may have a possible role in some pathological conditions. Aim of the present study was to verify whether HERV-W and K activation by EBV might occur also in vivo, during EBV infection, in pediatric liver transplant recipients.
METHODS: A total of 35 pediatric liver transplant (LT) patients who received LT at the University Hospital City of Science and Health of Turin, Regina Margherita Children's Hospital were included. The samples was grouped in EBV negative and positive.
RESULT: We found that HERV-K, and HERV-W expression levels showed no differences between the two groups (p=0.533 HERV-W and p=0.6017 HERV-K). There was not was a significant difference p=0.1894 and 0.1705 for HERV-W and –K respectively when we compared transplant recipients group with high EBV viral load vs others transplant recipients.
CONCLUSION: Our data suggest that EBV does not facilitate in vivo HERV activation.