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Rivista di Pediatria, Neonatologia, Medicina dell’Adolescenza
e Neuropsichiatria Infantile
Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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Minerva Pediatrica 2015 Nov 25
Study of helicobacter pylori infection in children with portal hypertensive gastropathy
Eskander A. E. 1, Mounir B. I. 2, Ghobrial C. M. 1, El-Karaksy H. M. 1 ✉
1 Department of Pediatrics, Kasr Alainy School of Medicine, Cairo University, Egypt;
2 Pathology, Kasr Alainy School of Medicine, Cairo University, Egypt
BACKGROUND: Data about the association of Helicobacter pylori (H. pylori) and portal hypertensive gastropathy (PHG) are scarce in children.
AIM: The present study aimed to fill the knowledge gap in this area.
METHODS: To achieve this goal we studied the prevalence of H. pylori infection in a group of infants and children with PHG using rapid urease test and histological demonstration of H. pylori in gastric mucosal biopsy obtained by upper gastrointestinal endoscopy. The results were compared to a control group who underwent endoscopy for other indications maily hematemesis and/or dyspepsia.
RESULTS: H. pylori was equally prevalent in both groups (~60%). Children with PHG were significantly stunted in height, had significantly lower hemoglobin, platelets and serum iron. Severe PHG was associated with higher grade of esophageal varices. Within the group with PHG, H. pylori infection was associated with lower hemoglobin, serum iron and serm ferritin. Moderate to severe PHG was more associated with H. pylori infection.
CONCLUSION: H. pylori infection was not more commonly associated with PHG, however, it might contribute to the severity of PHG. The synergistic effect of PHG and H. pylori infection might contribute to the retarded growth and iron deficiency status noted in this group.