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Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,532
Online ISSN 1827-1715
Machado F. C. 1, Vitalle M. S. 2, Franco M. 3
1 Division of Translational Medicine, School of Medicine, Federal University of São Paulo, São Paulo, Brazil;
2 Department of Pediatrics, School of Medicine, Federal University of São Paulo, São Paulo, Brazil;
3 Division of Nephrology, School of Medicine, Federal University of São Paulo, São Paulo, Brazil
AIM: A complex association has been observed between birth weight (BW) and depression/anxiety symptoms at various stages of life. The purpose of this study was to evaluate whether adolescents with low or insufficient BW were more likely to report depressive/anxiety symptoms.
METHODS: A cross-sectional study was conducted with 102 adolescents (40 boys and 62 girls).
RESULTS: Our results demonstrated that the incidence of depressive symptoms was 63% in the first BW quartile and 20% in the fourth quartile. Similarly, we observed that anxiety symptoms were present in 83% of the adolescents in the first BW quartile, followed by 36% in the fourth BW quartile. After adjustment, our study identified potential risk factors that were associated with anxiety symptoms, including female gender (P=0.026) and having a BW in the first quartile (P=0.049). Moreover, the adjusted odds of having depression were 4.5 times higher in adolescents with BW in the lowest quartile (P=0.035). We also found that the incidence of depressive symptoms among females was 61% in the first BW quartile and 30% in the fourth BW quartile and that it was 67% versus 12%, respectively, among males. Finally, a model that used anxiety symptoms as the dependent variable produced similar data.
CONCLUSION: Our findings suggest that a deleterious foetal environment appears to have a significant impact on psychiatric issues.