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Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,532
Online ISSN 1827-1715
Eke Gungor H. 1, Sahiner U. M. 1, Altuner Torun Y. 2
1 Kayseri Education and Research Hospital, Department of Pediatric Allergy and Immunology, Erkilet Kayseri, Turkey;
2 Kayseri Education and Research Hospital, Department of Pediatric Hematology, Erkilet Kayseri, Turkey
AIM: Forced expiratory flow between 25%and75% of vital capacity (FEF25-75%), a spirometric measure of small airways, may predict the presence of airway responsiveness both in asthmatics and in allergic rhinitics. We aimed to search the correlation between FEF25-75% and standard measures of spirometry (FEV1% and FEV1/FVC) in different clinical conditions, that is in children with asthma, in children with asthma and allergic rhinitis, in children with allergic rhinitis and in healthy children
METHODS: Children with asthma(n=116), asthma plus allergic rhinitis(n=25), allergic rhinitis(n=75) and healthy controls(n=52) were evaluated. Clinical examinations, spirometry and bronchodilation tests were performed.
RESULTS: In asthmatics there was a strong correlation between FEF25-75% and FEV1%(r=0.596, p<0.001); and between FEF25-75% and FEV1/FVC(r=0.740, p<0.001). In AR patients correlation between FEF25-75% and FEV1%(r=0.367, p=0.001); and between FEF25-75% and FEV1/FVC(r=0.534, p<0.001) were less prominent compared to asthmatics but they were still significant and strong. In children with both allergic rhinitis (AR) and asthma correlation between FEF25-75% and FEV1%(r=0.633, p=0.001) and between FEF25-75% and FEV1/FVC(r=0.539, p=0.005) were again significant. Pre-test FEV1% and FEF25-75% in AR patients were lower than that of the control subjects. After the bronchodilation, percentage change in the FEV1 in AR patients were significantly higher then the control subjects(p=0.010). AR patients showed significant increases in FEV1%, (p<0.001), FEF25-75%, (p<0.001) and , (p=0.001) after the bronchodilation test. Within the AR patients only 12/75(16.0%) showed bronchodilation with salbutamol. Among the ones with a FEF25-75% <65% FEV1% was normal in 6/43 (14%) patients in asthmatics and FEV1% was normal in 3/9 (33%) patients in asthma +AR patients.
CONCLUSION: Besides the FEV1% and FEV1/FVC, the FEF25-75% may be a useful and early spirometric parameter to evaluate the children with asthma and or AR.