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Rivista di Pediatria, Neonatologia, Medicina dell’Adolescenza
e Neuropsichiatria Infantile
Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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Minerva Pediatrica 2015 Jul 22
Comparison of ferrous sulfate, polymaltose complex and iron-zinc in iron deficiency anemia
Ozsurekci Y. 1, Unal S. 2, Cetin M. 2, Gumruk F. 2 ✉
1 Department of Pediatric Infectious Diseases, Hacettepe University Faculty of Medicine, Ankara, Turkey;
2 Department of Pediatric Hematology, Hacettepe University Faculty of Medicine, Ankara, Turkey
AIM: The purpose of this study was to compare the effectiveness of different oral iron preparations in children with iron deficiency anemia (IDA).
METHODS: Sixty children with IDA, aged between 6 months and 180 months, were randomly assigned into three treatment groups. Group I included children with IDA who received ferrous sulfate (Fe-S); Group II included children receiving iron polymaltose complexes (Fe-OH-PM), and Group III included children receiving a single preparation of combined iron and zinc (Fe-Zn). The effect of different iron preparations were evaluated and compared. The duration of treatment was 8 weeks. Hemoglobin (Hgb) levels, as well as other hematological parameters were determined at admission and the first, fourth, and eighth weeks of the treatment.
RESULTS: The Hgb levels of patients in all three groups were statistically higher in the fourth (p=0.001) and eighth (p<0.001) weeks compared to baseline; although there was no difference between the groups at the end of the treatment period (p >0.05).
CONCLUSION: Our results indicate that, Fe-OH-PM and Fe-Zn preparations may also be preferred as a choice like Fe-S for treatment of children with IDA.