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FASCICOLI E ARTICOLI   I PIÙ LETTI   eTOC

ULTIMO FASCICOLOMINERVA PEDIATRICA

Rivista di Pediatria, Neonatologia, Medicina dell’Adolescenza
e Neuropsichiatria Infantile

Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,532

Periodicità: Bimestrale

ISSN 0026-4946

Online ISSN 1827-1715

 

Minerva Pediatrica 2014 Nov 20

Effect of vitamin D on HbA1c levels of children and adolescents with diabetes mellitus type 1

Ordooei M. 1, Shojaoddiny-Ardekani A. 2, Hoseinipoor S.H. 3, Soleimanizad R. 4, Miroliai M. 5, Zare-Zardini H. 6, 7

1 Pediatric Endocrinologist, Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;
2 General practitioner, Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;
3 Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;
4 Ophthalmologist, Department of Ophthalmology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;
5 Pediatric Endocrinologist, Yazd Diabetes Research Center, Shahid Sadoughi, University of Medical Sciences, Yazd, Iran;
6 Young Researchers and Elite Club, Yazd Branch, Islamic Azad University, Yazd, Iran;
7 Department of Pediatric, Hematology, Oncology and Genetics Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran

AIM: Studies show the relationship between vitamin D deficiency and glucose metabolism disorders. The aim of this study is evaluation of the effect of vitamin D administration in management of diabetes mellitus type 1.
METHODS: We evaluated the effect of supplementation with vitamin D on HbA1c levels of children and adolescents with diabetes mellitus type 1. In this before-after study, 70 subjects with diabetes mellitus type 1 were enrolled. Fasting serum 25-hydroxyvitamin D, calcium, phosphate, alkaline phosphatase, glucose and HbA1c were measured at the initiation and after the administration of 50,000 IU of vitamin D3 biweekly for 3 months. The results were then compared using paired t-test. Between 70 patients, Five patients excluded from the study because they did not completed the study and finalyy, 65 subjects finished the study.
RESULTS: Finally, 65 patients including 35 children and 30 adolescents were recruited. Fortythree (66.1%) subjects had vitamin D deficiency (<30ng/ml). Vitamin D administration leads to decrease of fast blood sugar and HbA1c levels significantly in treated group without effect on calcium and alkaline phosphatase levels. So, No significant alterations occurred in calcium and alkaline phosphatase levels after supplementation with vitamin D.
CONCLUSION: This study showed that HbA1c may be reduced by administration of vitamin D to children and adolescents with diabetes mellitus type 1 without changing the dose of insulin.

lingua: Inglese


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