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MINERVA PEDIATRICA

Rivista di Pediatria, Neonatologia, Medicina dell’Adolescenza
e Neuropsichiatria Infantile


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Minerva Pediatrica 2016 December;68(6):478-86

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

Usefulness of fecal calprotectin determination in pediatric intestinal diseases

Chiara ROSSO 1, Gian P. CAVIGLIA 1, Rinaldo PELLICANO 2

1 Department of Medical Sciences, University of Turin, Turin, Italy; 2 Unit of Gastroenterology, Città della Salute e della Scienza-Molinette Hospital, Turin, Italy


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Calprotectin is a heterodimeric protein which belongs to the calcium-binding protein S100 family. Calprotectin is released by leukocytes at the site of inflammation and it can be detected in the feces where it remains stable for about a week. Hence, increased fecal calprotectin (FC) levels are found in several inflammatory conditions, mainly the inflammatory bowel diseases (IBD). In the setting of pediatric gastroenterology, the importance of FC has increased over time. This review aims to summarize the most recent findings concerning the role of FC in the algorithm of different inflammatory and non-inflammatory conditions among pediatric patients. Increasing evidences support the use of this biomarker for diagnosis, follow-up and evaluation of response to therapy of several pediatric gastrointestinal diseases, ranging from IBD to lymphocytic/ eosinophilic/ and nonspecific colitis and necrotizing enterocolitis. More efforts should be done to clarify the optimal cut-off of FC levels in patients younger than 5 years.

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Rosso C, Caviglia GP, Pellicano R. Usefulness of fecal calprotectin determination in pediatric intestinal diseases. Minerva Pediatr 2016 December;68(6):478-86. 

Corresponding author e-mail

caviglia.giampi@libero.it