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Minerva Pediatrica 2009 April;61(2):231-36

lingua: Inglese

Linfangiomatosi associata a interessamento scheletrico (malattia di Gorham): caso clinico e revisione della letteratura

Barbagallo M. 1,2, Incorpora G. 3, Magro G. 4, D’Amico S. 5, Pavone V. 6

1 Department of Paediatrics, University of Catania, Catania, Italy
2 Department of Paediatrics, Gravina e Santo Pietro Hospital, Caltagirone, Catania, Italy
3 Department of Paediatrics, Maria Paternò Arezzo Civil Hospital, Ragusa, Italy
4 Department G. F. Ingrassia Pathological Anatomy, University of Catania Catania, Italy
5 Orthopedic Division Department of Medical Surgical Science University of Catania, Catania, Italy


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Lymphangiomatosis is a well-recognized congenital benign tumour, frequently seen in infancy and childhood, characterized by the presence of multiple lymphangiomas. Diffuse lymphangiomatosis also involving bony tissue is called Gorham’s disease. This condition generally affects somatic soft tissue, where lymphatics are normally found. A predilection of this affection for bone, thoracic and neck involvement is well known, while involvement of abdominal viscera is very unusual. In bone this non malignant proliferation of lymphatic channels results in destruction and resorption of the osseous matrix. We report on a child in whom lymphangiomatosis involved both the bone and the spleen. A review of 166 cases is also reported.

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