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MINERVA ORTOPEDICA E TRAUMATOLOGICA
Rivista di Ortopedia e Traumatologia
Minerva Ortopedica e Traumatologica 2016 December;67(4):163-9
Evaluation of clinical efficacy of platelet rich plasma in osteoarthritis patients
Antonio CRESCIBENE 1, Marcello NAPOLITANO 2, Raffaella SBANO 3, Paolo GIGLIOTTI 4, Hesham ALMOLLA 5, Enrico COSTABILE 6, Rosina BOSCO 2
1 Orthopedics and Traumatology Unit, San Francesco di Paola Hospital, Paola, Cosenza, Italy; 2 Immunohematology and Transfusion Medicine Unit, Cosenza Hospital, Cosenza, Italy; 3 Radiology Unit, San Francesco di Paola Hospital, Paola, Cosenza, Italy; 4 Kidney and Transplantation Research Center, Cosenza Hospital, Cosenza, Italy; 5 Radiology Unit, Cosenza Hospital, Cosenza, Italy; 6 Orthopedics and Traumatology Unit, Cosenza Hospital, Cosenza, Italy
BACKGROUND: The aim of our work was to identify preliminary platelet laboratory values which may provide significant therapeutic indications from a prognostic point of view. We evaluated the following parameters: baseline platelet count, platelet-rich plasma (PRP) platelet recovery, PRP concentration factor, Western Ontario and McMaster University Arthritis (WOMAC) Index, Kellgren-Lawrence (K/L), Numeric Rating Scale Score, Age, Sex, BMI.
METHODS: Fifty-three patients treated with PRP articular injection were taken in consideration and these patients completed successfully 24 months follow-up. The patients were divided in two groups based on the K/L radiological classification. The first group with K/L grade between 0 and 2 and the second group with K/L grade between 3 and 4.
RESULTS: In the first group a constant increase in the WOMAC Score was registered, while in the second group less important increase in the WOMAC Score was noticed. Drawing conclusions we can sustain that patients with K/L between 0 and 2 have efficient treatment results. Patients with K/L Score between 3 and 4 expected results were less effective with less lasting wellbeing period.
CONCLUSIONS: The platelets count in whole blood and in the recovery percentage and the concentration factor does not seem to offer any prognostic indicator. On other side we can say that the initial platelet count is not directly correlated to the efficacy of the treatment.