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MINERVA ORTOPEDICA E TRAUMATOLOGICA
Rivista di Ortopedia e Traumatologia
Minerva Ortopedica e Traumatologica 2016 Giugno;67(2):75-8
Clinical usefulness of oral supplementation with curcumin phytosome in patients with radiculopathy due to spondyloarthritis or discopathy
Department of Surgery, Division of Spine Surgery, S. M. Maddalena Hospital, S. M. Maddalena-Rovigo, Italy
BACKGROUND: The aim of this study was to explore the efficacy and safety of curcumine phytosome (Meriva®) in reducing the pain due to radiculopathy, in patients affected with spine arthritis or discopathy.
METHODS: Thirty-six patients affected with radiculopathy seen in one Italian neurosurgical outpatients facility, were enrolled to participate in an open, not controlled study, and were treated with curcumine phytosome for 100 days. Pain, motor functionality and other symptoms were assessed at baseline, 50 and 100 days.
RESULTS: There was a marked reduction in pain rating, statistically significant both at 50 and 100 days from baseline. The reduction was statistically significant, both in the intention-to-treat population and in the observed cases. A mild, not clinically significant, reduction in motor functionality was observed at day 50 but not at day 100. No adverse events were recorded.
CONCLUSIONS: This exploratory study highlights the clinical usefulness of curcumine phytosome long term treatment of pain due to radiculopathy, due from spine arthritis or discopathy.