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MINERVA ORTOPEDICA E TRAUMATOLOGICA
Rivista di Ortopedia e Traumatologia
LA CHIRURGIA DELLA SPALLA
Minerva Ortopedica e Traumatologica 2014 October;65(5):321-9
Multimodal analgesia with pregabalin and magnesium sulfate for arthroscopic rotator cuff repair
Jo C. H. 1, Shin J. S. 1, Shin W. H. 1, Huh J. 2
1 Department of Orthopedic Surgery, SMG‑SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea;
2 Department of Anesthesiology and Pain Medicine, SMG‑SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea
AIM: The aim of the present study was to evaluate the safety and the efficacy of a mulitimodal analgesia (MMA) with pregabalin and magnesium sulfate for arthroscopic rotator cuff repair.
METHODS: From April to July 2011, 27 consecutive patients undergoing arthroscopic rotator cuff repair were treated with MMA with pregabalin and magnesium sulfate (MMA-Pg/Mg group). A total of 27 patients undergoing the same procedure but without MMA were matched retrospectively (Control Group). The primary outcome measure was the visual analog scale (VAS) for pain. Secondary outcome measures were patient-controlled analgesia (PCA) consumption, rescue morphine consumption, night awakening, and narcotics-related side effects.
RESULTS: The MMA-Pg/Mg group showed significantly less postoperative pain during the first 48 hours after surgery. The MMA-Pg/Mg group also demonstrated reduced PCA consumption for up to 24 hour postoperatively (P=0.049) and rescue morphine consumption during the first 30 hours postoperatively (P=0.042). No significant differences were observed between the two groups in regard to side effects.
CONCLUSION: The use of MMA with pregabalin and magnesium sulfate in arthroscopic rotator cuff repair showed a sufficient time (up to 48 hours) of pain reduction and less rescue morphine consumption compared without pregabalin and magnesium sulfate.