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Minerva Oftalmologica 2017 March;59(1):14-29

DOI: 10.23736/S0026-4903.17.01768-8

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Role of anti-VEGF agents for proliferative diabetic retinopathy

Chiya BARRETT 1, Orit BARRETT 2, Noam YANCULOVICH 1, Ran MATLOV KORMAS 1, Jaime LEVY 1

1 Department of Ophthalmology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Soroka University Medical Center, Israel; 2 Department of Medicine, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel


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BACKGROUND: Untreated proliferative diabetic retinopathy (PDR) can cause severe visual loss and even blindness. Current treatment of PDR consists of laser panretinal photocoagulation. In recent years, intravitreal injections of anti-vascular endothelial growth factor (VEGF) drugs have been widely used for the treatment of retinal diseases. In this review we summarize the different types of anti-VEGF treatments available for PDR, current treatment regimens, risks, costs and complications.
EVIDENCE ACQUISITION: A comprehensive search was made using PUBMED and Cochrane Central Register of Controlled Trials, with English language articles only included until August 2016 and containing research regarding PDR and anti-VEGF treatments.
EVIDENCE SYNTHESIS: Review of level II studies show that: 1) intravitreal bevacizumab injections previous to vitrectomy cause a reduction in bleeding time during surgery and lower rates of postoperative bleeding; 2) intravitreal ranibizumab injections before vitrectomy showed lower rates of intraoperative bleeding and shorter operating time; 3) intravitreal bevacizumab treatment for neovascular glaucoma is effective in reducing complication rates of Ahmed Valve implantation surgery. Other studies are of level II of evidence or lower.
CONCLUSIONS: Intravitreal bevacizumab and ranibizumab may be helpful in cases of proliferative diabetic retinopathy.


KEY WORDS: Diabetic retinopathy - Endothelial growth factor - Intravitreal injection

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Issue published online: April 18, 2017

Per citare questo articolo

Barrett C, Barrett O, Yanculovich N, Matlov Kormas R, Levy J. Role of anti-VEGF agents for proliferative diabetic retinopathy. Minerva Oftalmol 2017;59:14-29. DOI: 10.23736/S0026-4903.17.01768-8

Corresponding author e-mail

ljaime@bgu.ac.il