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Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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Minerva Medica 2017 Mar 01

DOI: 10.23736/S0026-4806.17.04703-6


lingua: Inglese

High expression of long noncoding RNA CCAT2 indicates poor prognosis of gastric cancer and promotes cell proliferation and invasion

Sheng-Wen WU 1, Yan-Ping HAO 2, Jing-Hui QUI 2, Dong-Bo ZHANG 3, Cheng-Gong YU 2, Hui-Wen LI 4

1 Department of General Surgery, The Affiliated Jianhu Hospital of Nantong University, Jianhu People’s Hospital, Jianhu, Jiangsu Province, China; 2 Department of Gastroenterology, The First People’s Hospital of Yancheng City, Yancheng City, China; 3 Department of Anesthesiology, The Third People’s Hospital of Yancheng City, Yancheng City, China; 4 Department of Interventional Radiology, The Affiliated Yancheng hospital of Southeast University Medical College, Yancheng Third People’s Hospital, Yancheng, Jiangsu Province, China


BACKGROUND: Numerous studies have demonstrated that long noncoding RNAs (lncRNAs) have many biological functions and play crucial roles in various human cancers, including cancer development, metastasis and prognosis of cancer patients. CCAT2, a novel long non-coding RNA, has been identified that is correlated with several different types of cancers. However, the role of lncRNA CCAT2 in gastric cancer (GC) patients is unknown. The purpose of our research was to investigate the function and prognostic significance of lncRNA CCAT2 expression in GC patients.
METHODS: Expression of lncRNA CCAT2 was examined in 208 paired normal and cancerous gastric tissues. Molecular and cellular techniques were used to explore the biological function of lncRNA CCAT2 in GC cells. Kaplan-Meier method and Cox proportional hazards model were used to analyz the prognostic significance of lncRNA CCAT2 expression.
RESULTS: The results showed that lncRNA CCAT2 was upregulated in GC tissues (P=0.000), and positively correlated with TNM stage (P=0.029), lymphatic invasion (P=0.042) and nervous invasion (P=0.024) in GC patients. Furthermore, we also found that high expression of lncRNA CCAT2 was an unfavorable prognostic factor in GC patients. Silencing of lncRNA CCAT2 inhibits gastric cancer cell proliferation and invasion.
CONCLUSIONS: lncRNA CCAT2 may serve as a tumor promoter and a new predictive prognostic factor for human gastric cancer.

KEY WORDS: Long noncoding RNA - CCAT2 - Gastric cancer - Prognosis

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