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Rivista di Medicina Interna

Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,236

Periodicità: Bimestrale

ISSN 0026-4806

Online ISSN 1827-1669


Minerva Medica 2016 Giugno;107(3 Suppl 1):12-9



The immunobiological and clinical role of vitamin D in obstructive lung diseases

Paolo SOLIDORO 1, Michela BELLOCCHIA 1, Fabrizio FACCHINI 2

1 Pulmonary Medicine Unit, Department of Cardiovascular and Thoracic Surgery, Città della Salute e della Scienza University Hospital, University of Turin, Turin, Italy; 2 Pulmonary Medicine Unit, Vittorio Veneto Hospital, Treviso, Italy

Vitamin D is a fat-soluble vitamin, which is obtained by conversion of 7-dehydrocholesterol in the skin by UV ray and by diet. Its role on bone mineralization has been known for over two hundred years, while its non-skeletal effects have been acknowledged only in the last few years. The discovery of important vitamin D properties on the innate and adaptive immune system created a lot of interest in a potential role of vitamin D on diseases characterized by heightened inflammation and oxidative response, and impaired antimicrobial response, such as asthma and chronic obstructive pulmonary disease (COPD). Recent studies have demonstrated that vitamin D and its deficiency have a number of biological effects which are potentially important in altering the pathogenesis and severity of both asthma and COPD. Vitamin D may improve lung function and response to steroids therapy, reduce airway remodeling and disease exacerbations. The aim of this study is to review the role of Vitamin D in asthma and COPD.

lingua: Inglese


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