Home > Riviste > Minerva Medica > Fascicoli precedenti > Minerva Medica 2016 Giugno;107(3) > Minerva Medica 2016 Giugno;107(3):131-9

ULTIMO FASCICOLOMINERVA MEDICA

Rivista di Medicina Interna


Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,236


eTOC

 

ORIGINAL ARTICLES  


Minerva Medica 2016 Giugno;107(3):131-9

lingua: Inglese

Prevention program for Clostridium difficile infection: a single-centre Serbian experience

Snezana BRKIC 1, Rinaldo PELLICANO 2, Vesna TURKULOV 1, Marija RADOVANOVIC 3, Ludovico ABENAVOLI 4

1 Medical Faculty Novi Sad, Clinical Centre of Vojvodina for Infectious Diseases, University of Novi Sad, Novi Sad, Serbia; 2 Department of Gastro-Hepatology, Molinette Hospital, Turin, Italy; 3 Miofarm Doo, Novi Sad, Serbia; 4 Department of Health Sciences, University Magna Graecia, Catanzaro, Italy


PDF  ESTRATTI


BACKGROUND: Clostridium difficile (C. difficile) diarrhea is a common, iatrogenic, nosocomial disease with a worldwide diffusion. Recent studies reported that the incidence of C. difficile infection (CDI) is rising, due to aging of the population and to greater prevalence of hypervirulent strains. We investigated whether the application of a prevention program lead to a decline in the incidence of intrahospital CDI.
METHODS: The study was designed as observational, to compare the efficacy of Schülke preventive program with the standard protocols, in a period of 4 months. For every patient with community-onset healthcare facility-associated (HCFA) CDI, we randomly selected four controls (1:4) with the same ICD code but without HCFA CDI. For statistical analysis the nonparametric, one-way ANOVA, univariate regression analysis, univariate analysis of variance, and Welch and Brown-Forsythe Test were used.
RESULTS: Clinical features of HCFA CDI were typical. HCFA CDI group was significantly older than control group (P=0.008 and F=6.686; Partial Eta Square=0.013). Patients with HCFA CDI stayed significantly longer in hospital (P=0.000 and F=69.379; Partial Eta Square=0.117). Acquiring CDI prolonged the hospitalization of 14.52 days. HCFA CDI significantly increases the total cost of hospitalization as well as each element of the price respectively. With the application of the prevention program the annual incidence of CDI dropped from 49.01 in 2013 to 18.22/10000 bed days in 2014.
CONCLUSIONS: Applying Schülke preventive program, implemented in 2014, has led to significant savings for the hospital compared to previous methods.

inizio pagina