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Minerva Medica 2016 April;107(2):101-7

lingua: Inglese

Long non-coding RNA-LET can indicate metastasis and a poor prognosis: a meta-analysis

Fang T. LIU 1, Pei Q. ZHU 1, Yang X. OU 1, Quan S. LIN 2, Cheng QIU 1, Hong L. LUO 1

1 Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China; 2 Department of Respiratory Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, China


INTRODUCTION: Recent studies have reported that long non-coding RNA low expression in tumor (lncRNA-LET) was down-regulated in several cancers. The current meta-analysis aims to determine whether lncRNA-LET can be used as a potential biomarker for metastasis and prognosis.
EVIDENCE ACQUISITION: We collected all relevant papers by searching multiple electronic databases (PubMed, EMBASE, Google Scholar, CNKI, Wanfang Database) and explored the association between the expression levels of lncRNA-LET and lymph node metastasis (LNM), distant metastasis (DM) and overall survival (OS).
EVIDENCE SYNTHESIS: A total of 383 patients from four studies were finally included. The meta-analysis results showed that LNM occurred more frequently in patients from the lncRNA-LET low expression group than in patients from the lncRNA-LET overexpression group (OR=4.56, 95% CI 2.92-7.12, P<0.00001), and a similar result was observed between lncRNA-LET expression and DM (OR=4.77, 95% CI 2.29-9.94, P<0.0001). Additionally, we found that patients with low expression of lncRNA-LET had a poorer OS than those with lncRNA-LET overexpression (HR=2.39, 95% CI 1.57-3.21, P=0.000).
CONCLUSIONS: lncRNA-LET may serve as a common molecular marker for metastasis and prognosis in human cancers.

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